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Prof. Dr. med. Andreas Neubauer

Direktor der Klinik für Hämatologie, Onkologie und Immunologie

Baldingerstrasse
35033 Marburg

Telefon: 06421/58-66273
Fax: 06421/58-66358

E-mail: sekretariat.onkologie(at)med.uni-marburg.de

Vita

Persönliches

Geboren 1958

Forschungsschwerpunkte

Onkologie / Tumorbiologie, Leukämie, Magentumore, Infektionsbiologie, allogene Blutstammzelltransplantationen, Resistenzen.

Andreas Neubauer ist Mediziner mit Schwerpunkt Innere Medizin und Onkologie. Er erforscht insbesondere Leukämien, Magentumore sowie Bronchialkarzinome und Nierenzellkarzinome. Außerdem ist er Spezialist für allogene Blutstammzelltransplantationen. Um neue Therapiekonzepte zu entwickeln, führt er in seiner Forschung Tumor-, Immun- und Infektionsbiologie zusammen.

Akademischer und beruflicher Werdegang
 

seit 1999 Direktor der Klinik für Hämatologie, Onkologie und Immunologie, Zentrum Innere Medizin, Philipps-Universität Marburg

1996 - 1998 C3-Professur für Innere Medizin, Schwerpunkt Hämatologie / Onkologie am Universitätsklinikum Carl Gustav Carus, Dresden

1993 Habilitation an der Freien Universität Berlin für das Fach Innere Medizin

1984 - 1996 Abteilung für Innere Medizin, Schwerpunkt Hämatologie/Onkologie, Freie Universität Berlin, seit 1993 Oberarzt

1992 „Adjunct Instructor”, Department of Medicine, School of Medicine des Lineberger Comprehensive Cancer Center an der University of North Carolina at Chapel Hill, USA

1988 - 1990 Postdoctoral Fellow am Lineberger Cancer Research Center, University of North Carolina, Chapel Hill, USA

1985 - 1986 Stipendiat der DFG, Abteilung für experimentelle Krebszellforschung, Max-Planck-Institut für Biochemie, Martinsried

1983 -1984 Arzt in der Abteilung Nephrologie, Dialysezentrum Berlin Charlottenburg und Freie Universität Berlin, Klinikum Charlottenburg

1983 Promotion an der Universitätskinderklinik Hamburg- Eppendorf

1982 - 1983 Studium an der Freien Universität Berlin

1980 - 1982 Studium an der Universität Hamburg

1976 - 1980 Studium an der Freien Universität Berlin

Funktionen in wissenschaftlichen Gesellschaften und Gremien

Mitglied der Ethikkommission der Philipps-Universität Marburg(seit 1999)

Mitglied im wissenschaftlichen Beirat der Deutschen Gesellschaft für Hämatologie und internistische Onkologie
(seit 1997)

Mitglied im wissenschaftlichen Beirat der Deutschen José Carreras Leukämiestiftung

Projektkoordination, Mitgliedschaft in Verbundprojekten

DFG-Projekt „Epigenetik des nukleären Onkoproteins Ski in der AML“, Teilprojekt zu SPP 1463: „Epigenetic regulation of normal hematopoiesis and its dysregulation in myeloid neoplasia“
(seit 2010)

Sprecher des DFG-Projekts “A synthetic lethal screen to identify novel targets for therapy in acute myeloid leukemia“, Teilprojekt zur Klinischen Forscherguppe KFO 210 “Genetics of Drug Resistance in Cancer”
(2008 - 2015)

DFG-Projekt „Ras und Ski in der akuten Leukämie“, Teilprojekt zu TRR 17 „Ras-abhängige Signalwege in humanen Tumoren“
(2004 - 2013)

Publikationen

Neubauer A, Thalmann U, Musch R, Grosser H, Loddenkemper R, Huhn D:
Prospektiver Vergleich der diagnostischen Wertigkeit von Zytologie und Immunzytologie bei thoraskopisch-bioptisch unter suchten Pleuraergüssen.
Klin Wschr 65: 400-406, 1987   

Neubauer A, Sauer H, Valet G:
Cytostatic drug testing in human leukemias by means of multiparametric flow cytometry.
Blut 55: 433-445, 1987

Neubauer A, Huhn D:
Monoclonal antibody Ki67 as a proliferation marker.
(Letter) Br J Haematol 67: 495, 1987

Neubauer A:
Reizhusten durch ACE-Hemmer: Dosierungsschema bedenken.
(Leserbrief) Münch Med Wochenschr 129: 18, 1987

Pralle H, Zwingers T, Boedewadt S, Bross K, Dörken B, Gamm H, Ho AD, Parwaresch RM, Schmitz N, Papendick U, Asshoff D, Bremer K, Euler H, Fischer T, Ganser A, Goldmann A, Hartlapp J, Hazungs J, Heinen U, Heyll A, Kraft J, Lohmeyer J, Meier P, Neubauer A, Nowicki L, Pflüger K, Sass R, Schmidt W, Schuster D, Straif K, Westerhausen M:
Primäre Behandlung der Haarzelleukämie mit niedrigdosiertem humanem rekombinantem IFNalpha2c im Vergleich zur Therapie nach Splenektomie.
Onkologie 10: 5-10, 1987.

Pralle H, Zwingers T, Boedewadt S, Bross K, Doerken B, Gamm H, Ho AD, Parwaresch RM, Schmitz N, Papendick U, Asshoff D, Bremer K, Euler H, Fischer T, Ganser A, Goldmann A, Hartlapp J, Hayungs J, Heinen U, Heyll A, Kraft J, Lohmeyer J, Meier P, Neubauer A, Nowicki L, Pflüger K, Sass R, Schmidt W, Schuster D, Straif K, Westerhausen M:
A prospective multicenter trial with human recombinant alpha2c interferon in hairy cell leukemia before and after splenectomy.
Leukemia 1:337-40, 1987

Neubauer A, Musch R, Thalmann U, Laser J, Grosser H, Lodden­kem­per R, Huhn D:
Evidence for cross reactivity of "carcinoma- specific" monoclonal antibody KC4 with activated mesothelial cells and phytohemagglutinin stimulated lymphocytes.
Oncology 45:380-3, 1988

Schmidt CA, Fiek T, Neubauer A, Huhn D:
HIV Infektion durch Nadelstichverletzung (Leserzuschrift).
Deut Med Wschr 113: 76, 1988

Pralle H, Bartel A, Boedewadt S, Bross K, Bruhn HD, Dörken B,.Drees N, Essers U, Fuhr H, Gamm H, Ho AD, Parwaresch RM, Papendick U, Asshoff D, Bremer K, Euler H, Fischer T, Ganser A, Vonnegut A, Hayungs J, Heinen U, Heyll A, Kraft J, Neubauer A, Nowicki L, Pfannschmidt G, Pflüger K, Sass R, Schmidt W, Schuster D, Schober I, Schrappe-Bächer M, Schwöbel HD, Straif K, Vaupel H, Zwingers T:
Interferon alpha für die Therapie der HCL: Ergebnisse von drei prospektiven multizentrischen Studien in der BRD.
Onkologie 11: 44-47, 1988.

Siegert W, Huhn D, Neubauer A, Brittinger G, Engelhard M et al:
Multizentrische prospektive risikoadaptierte Studie zur Therapie von Non-Hodgkin Lymphomen hoher Malignität.
Onkologie 11: 30-34, 1988.

Neubauer A, v.Lessen A, Huhn D:
Methodenabhängigkeit der T- Zellsubpopulationsbestimmung.
Dtsch Med Wschr, 114:414-416, 1989.

Neubauer A, Serke S, Siegert W, Kroll W, Musch R, Huhn D:
A flow cytometric assay for the determination of cell proliferation with a monoclonal antibody directed against DNA-methyl­trans­ferase.
Br J Haematol 72:492-496, 1989.

Serke S, Neubauer A, Huhn D:
Expression of transferrin receptor parallels state of proliferation in HL60 cells.
(letter)Br J Haematol 72:297-299, 1989.

Serke S, Neubauer A, Huhn D:
Lymphocytosis of large granular lymphocytes: proof of monoclonality of the LGL population and benign clinical course.
Klin Wschr 67:588-591, 1989.

Serke S, Stein H, Anagnostopoulos I, Schmidt C, Neubauer A, Siegert W, Huhn D:
Acute leukemia with B and T-lymphoid and myeloid characteristics in a patient with a myelodyplastic syn­drome: a case report.
Br J Haematol 72:110-111, 1989.

Serke S, Neubauer A, van Lessen A:
Binding of mitogenic plant lectins to human lymphocyte subpopulations: a flow cytometric analysis.
J Immunol Methods 121:231-235, 1989.

Neubauer A, Herbst H, Rochlitz C, Siegert W, Schmidt C, Huhn D:
Immunocytochemical detection of p21 ras expression in fresh human leukemic cells and cell lines lines.
Blut 59:460-463, 1989.

Cogswell PC, Morgan R, Dunn M, Neubauer A, Nelson P, Poland- Johnston NK, Sandberg AA, Liu E:
Mutations of the ras protoonco­genes in chronic myelogeneous leukemia: a high incidence of ras mutations in bcr/abl negative CML.
Blood 74:2629-2633, 1989.

Thompson-Moya L, Martin T, Heuft HG, Neubauer A, Herrmann R:
Case report: Allergic reaction with immune hemolytic anemia resulting from chlorambucil.
Amer J Hematol 32:230-231, 1989.

Neubauer A, Valet G, Huhn D:
Flow cytometric determination of intracellular pH, esterase-concentration and cell-volume in human leukemic cell lines following in-vitro cytostatic drug incubation.
Anal Cell Pathol 2:49-58, 1989.

Neubauer A, Neubauer B, Liu E:
Polymerase chain reaction based assay to detect allelic loss in human DNA: Loss of beta-interferon gene in chronic myelogeneous leukemia.
Nucl Acids Res 18: 993-998, 1990.

Grosser H, Neubauer A, Musch R, Thalmann U, Huhn D, Lodden­kemper R:
CEA as a tumor marker on the cell surface and in the exsudate: Comparison in thoracoscopy examined pleural effusions.
Pneumologie 44, Suppl 1: 529-530, 1990.

Ball ED, Mills LE, Neubauer A, Liu E:
Detection of minimal acute myeloid leukemia cells in bone marrow by probing for mutated ras oncogenes using the polymerase chain reaction.
Prog Clin Biol Res 333: 499-506, 1990.

Neubauer A, Shannon K, Liu E:
Mutations of the ras proto­oncogenes in childhood monosomy 7.
Blood 77 (3): 594-598, 1991.

Chen L, Neubauer A, Kurisu W, Waldman F, Ljung B, Goodson W, Goldman E, Moore D, Balazs M, Liu E, Mayall B, Smith H:
A gene other than p53 on the short arm of chromosome 17 is associated with high proliferative capacity and DNA aneuploidy in primary human breast cancer.
Proc Natl Acad Sci USA, 88:3847-51.

O'Bryan J, Frye RA, Cogswell P, Neubauer A, Kitch B, Prokop C, Espinoza R, Le Beau MM, Earp HS, Liu E:
axl, a transforming gene isolated from primary human myeloid leukemia cells, encodes a novel receptor tyrosine kinase.
Mol Cell Biol 11:5016-5031, 1991.

Effert P, Frye RA, Neubauer A, Liu E, Walther P:
Human papillomavirus subtypes 16 and 18 are not involved in human prostate carcinogenesis: Analysis of archival human prostate cancer specimens by differential polymerase chain reaction.
J Urol, 147:192-196, 1992.

Effert P, Neubauer A, Walther P, Liu E:
Alterations of the p53 gene are associated with the progression of a human prostate carcinoma.
J Urol 147: 789-793, 1992.

Neubauer A, Neubauer B, He M, Effert P, Iglehart D, Frye RA, Liu E:
Technical report: Analysis of gene amplification in archival tissue by differential polymerase chain reaction.
Oncogene 7(5): 1019-1025, 1992.

Schmidt CA, Oettle H, Neubauer A, Seeger KH, Thiel E, Huhn D, Siegert W, Ludwig WD:
Rearrangements of T-cell receptor delta, gamma and beta genes in acute myeloid leukemia coexpressing T-lymphoid features.
Leukemia 6:1263-1267, 1992.

Taylor J, Sandler D, Bloomfield C, Shore D, Ball E, Neubauer A, McIntyre R, Liu E:
ras oncogene activation and occupational exposure in acute myeloid leukemia.
J Natl Cancer Inst, 84:1626-1632, 1992.

Rochlitz CR, de Kant E, Neubauer A, Heide I, Böhmer R, Huhn D, Herrmann R:
mdr1 expression in chronic lymphocytic leukemia.
Ann Hematol, 65: 241-246, 1992.

Neubauer A, He M, Schmidt CA, Huhn D, Liu E:
Genetic alterations in the p53 gene in the blast crisis of chronic myelogeneous leukemia: Analysis by polymerase chain reaction based techniques.
Leukemia 7: 593-600, 1993.

Neubauer A, O`Bryan JP, Fiebeler A, Schmidt CA, Huhn D, Liu E:
axl, a novel receptor tyrosine kinase isolated from cells of chronic myelogeneous leukemia.
Sem Hematol 30 (3, Suppl 3): 34, 1993.

Neubauer A, de Kant E, Rochlitz Ch, Laser J, Zanetta M, Oertel J, Herrmann R, Huhn D:
Altered expression of the retinoblastoma gene in chronic lymphocytic leukemia.
Br J Haematol, 85: 498-503, 1993.

Rochlitz C, Heide I, de Kant E, Neubauer A, Schmidt CA, Neuhaus P, Huhn D, Herrmann R:
Molecular alterations in a patient with Turcot's syndrome.
Br J Cancer, 68:519-23, 1993.

Neubauer A, Brendel C, Vogel D, Schmidt CA, Heide I, Huhn D:
Detection of p53 mutations using non-radioactive SSCP-analysis: p53 is not frequently mutated in myelodysplastic syndromes.
Ann Hematol, 67:223-226, 1993.

Seelig R, Schranz P, Bottner C, Neubauer A, Seelig HP, Renz M:
The chronic myelocytic cell line K562 contains minor (m) as well as major (M) BCR/ABL fusion mRNAs.
Leukemia 7, 1886-1887, 1993.

Lefterova P, Negrin R, Neubauer A, Huhn D, Blume K, Schmidt-Wolf I:
Efficient generation and characterization of tumor cell subclones with different adhesion pathways involved in cell lysis.
Hematologica, 78: 353-358, 1993

Schmidt CA, Przybylsky G, Vogel D, Ludwig WD, Oettle H, Neubauer A, Siegert W:
ras point mutations occur in acute myeloid leukemias with illegitimate T-cell receptor delta gene rearrangement.
Leukemia 8, 102-105, 1994.

Neubauer A, Greenberg P, Negrin R, Ginzton N, Liu E:
Mutations in the ras protooncogene in patients with myelodysplastic syndromes.
Leukemia, 8: 638-641, 1994.

Neubauer A, Dodge R, George St, Davey FR, Silver R, Schiffer Ch, Mayer RJ, Ball E, Wurster-Hill D, Bloomfield C, Liu E:
Prognostic importance of mutations in the ras protooncogenes in de novo acute myeloid leukemia.
Blood, 83: 1603-1611, 1994.

Schmidt CA, Neubauer A, Seeger KH, Rochlitz CR, Binder T, Oettle H, Henze G, Liu E, Huhn D, Siegert W:
Detection of allelic loss within the ß1-interferon gene in childhood acute lymphoblastic leukemia using differential PCR.
Ann Hematol, 68: 171-174, 1994.

Jörres A, Gahl G, Topley N, Neubauer A, Ludat K, Müller C, Passlick-Deetjen J:
in vitro biocompatibility of alternative CAPD fluids; comparison of bicarbonate-buffered and glucose polymer based solutions.
Nephrology Dialysis Transplantation, 9: 785-790, 1994.

Neubauer A, Fiebeler A, Graham DK, O'Bryan JP, Schmidt CA, Barckow P, Serke S, Siegert W, Snodgrass HR, Huhn D, Liu ET:
The expression of axl, a transforming receptor tyrosine kinase, in normal and malignant hematopoiesis.
Blood 84: 1931-1941, 1994.

Topley N, Petersen MM, Mackenzie R, Neubauer A, Stylianou E, Kaever V, Davies M, Coles GA, Jörres A, Williams JD:
Human peritoneal mesothelial cell prostaglandin synthesis: induction of cyclooxygenase mRNA ma peritoneal macrophage-derived cytokines.
Kidney Int, 900-909, 1994.

Schmidt-Wolf IGH, Huhn D, Neubauer A, Wittig B: Clinical protocol:
interleukin-7 gene transfer in patients with metastatic colon carcinoma, renal cell carcinoma, melanoma, or with lymphoma.
Human gene therapy 5:1161-1168, 1994.

Neubauer A, Liu E:
Respiratory burst activity in MDS and MPS patients.
Br J Haematol 88 (3): 663-664, 1994.

Vogel D, Heide I, Stenzel E, Thiede C, Rochlitz C, Neubauer A:
SSCP-Analyse von Mutationen im p53-Tumorsuppressor-Gen mittels Hydrolink-Gel-Elektrophorese.
Serva News 4: 25-26, 1994.

Scheffold C, Brand K, Johnston V, Lefterova P, Degen B, Schöntube M, Huhn D, Neubauer A, Schmidt-Wolf IGH:
Potential of autologous immunologic effector cells for bone marrow purging in patients with chronic myeloid leukemia.
Bone marrow transplantation 15:33-39, 1995.

Ritter M, de Kant E, Huhn D, Neubauer A:
Detection of calcitonin gene methylation in human leukemias using differential polymerase chain reaction.
Leukemia 9: 915-922, 1995.

Bayerdörffer E, Neubauer A, Rudolph B, Thiede C, Lehn N, Eidt S, Stolte M, and the MALT lymphoma study group:
Regression of primary gastric lymphoma of mucosa associated lymphoid tissue after cure of Helicobacter pylori infection.
Lancet 345:1591-1594, 1995.

Thiede C, Bayerdörffer E, Blasczyk R, Wittig B, Neubauer A:
Simple and sensitive detection of mutations in the ras protooncogenes using PNA-mediated PCR clamping.
Nucl Acids Res, 24: 983-4, 1996.

Blasczyk R, Ritter M, Thiede C, Wehling J, Hintz G, Neubauer A, Riess H:
Simple and rapid detection of factor V Leiden by allele-specific PCR amplification.
Thrombosis and Haemostasis, 75: 757-759, 1996.

Unterhalt M, Herrmann R, Tiemann M, Parwaresch R, Stein H, Trümper L, Nahler M, Reuss-Bost M, Tirier C, Neubauer A, Freund M, Kreuser E, Dietzfelbinger H, Bodenstein H, Engert A, Stauder R, Eimermacher H, Landys K, Hiddemann W:
Prednimustine, mitoxantrone (PmM) vs. cyclophosphamide, vincristine, prednisone (COP) for the treatment of advanced low-grade non-Hodgkin's lymphoma.
Leukemia 10: 836-843, 1996.

Aulitzky WE, Neubauer A, Kolbe K, Schneller F, Busemann C, Schleiermacher E, Peschel C, Siegert W, Huber C, Huhn D:
Preliminary results of stem cell mobilization in chronic myeloid leukemia with a moderate intensity chemotherapy regimen and G-CSF or G-CSF plus IL-3.
Bone marrow transplantation 17, Suppl 3, S67-S69, 1996.

Nagel S, Schmidt M, Thiede C, Huhn D, Neubauer A:
Quantification of bcr-abl transcript numbers in chronic myelogenous leukemia using standardized, internally controlled competitive differential PCR.
Nucleic Acids Res, 24: 4102-4103, 1996.

Riewald M, Hintz G, Ritter M, Schmidt M, Neubauer A, Riess H:
High sensitivity and specificity of a coagulation assay for the detection of heterozygous and homozygous factor V Leiden based resistance to activated protein C (Letter).
Blood, 88: 4398-4399, 1996.

Seliger B, Papadileris S, Vogel D, Hess G, Brendel C, Störkel S, Oertel J, Kolbe K, Huber C, Huhn D, Neubauer A:
Analysis of the p53 and MDM-2 gene in acute myeloid leukemia.
Eur J Haematol 57: 230-240, 1996.

Neubauer A, Burchert A, Maiwald C, Gruss HJ, Serke S, Huhn D, Wittig B, Liu E:
Recent progress on the role of axl, a receptor tyrosine kinase, in malignant transformation of myeloid leukemias.
Leuk Lymphoma, 25: 91-96, 1997.

Mackenzie RK, Topley N, Neubauer A, Coles GA, Williams JD:
Staphylococcal exoproducts down-regulate cyclooxygenase 1 and 2 in peritoneal macrophages.
J Lab Clin Med 129: 23-34, 1997.

Rudolph B, Bayerdörffer E, Ritter M, Müller S, Thiede C, Neubauer B, Lehn N, Seifert E, Otto P, Hatz R, Stolte M, Neubauer A:
Is the polymerase chain reaction or cure of Helicobacter pylori infection of help in the differential diagnosis of early gastric MALT lymphoma?
J Clin Oncol, 15: 1104-1109, 1997.

Heide I, Thiede C, Sonntag T, Kant E, Neubauer A, Jonas S, Peter F, Neuhaus P, Herrmann R, Rochlitz C:
The role of p53 in the metastatic progression of colorectal cancer.
Eur J Cancer, 33: 1314-1322, 1997.

Bayerdörffer E, Miehlke S, Neubauer A, Stolte M:
Gastric MALT-lymphoma and Helicobacter pylori infection.
Aliment Pharmacol Ther, 11 Suppl 1: 89-94, 1997.

Neubauer A, Thiede C, Morgner A, Alpen B, Ritter M, Neubauer B, Wündisch T, Ehninger G, Stolte M,Bayerdörffer E:
Cure of Helico­bacter pylori infection and duration of remission of low-grade gastric MALT lymphoma.
J Natl Cancer Inst 89: 1350 - 1355, 1997.

Sackmann M, Morgner A, Rudolph B, Neubauer A, Thiede C, Schulz HD, Kraemer W, Boersch G, Rohde P, Seifert E, Stolte M, Bayerdörffer E:
Regression of gastric MALT lymphoma after eradication of Helicobacter pylori is predicted by endosonographic staging.
Gastroenterology 113: 1087 - 1090, 1997.

Finke S, Trojaneck B, Möller P, Schadendorf D, Neubauer A, Huhn D, Schmidt-Wolf IG:
Increase of cytotoxic sensitivity of primary human melanoma cells transfected with the interleukin-7 gene to autologous and allogeneic immunologic effector cells.
Cancer Gene Ther 4: 260-268, 1997.

Ritter M, Thiede C, Schäkel U, Schmidt M, Alpen B, Pascheberg U, Mohr B, Ehninger G, Neubauer A:
Underestimation of inversion (16) in acute myeloid leukemia using standard cytogenetics as compared with polymerase chain reaction: Results of a prospective investigation.
Br J Haematol 98: 969 - 972, 1997.

Ruhnke M, Grosch-Wörner I, Steinmüller A, Neubauer A:
Molekulare Epidemiologie von Candida-Infektionen bei HIV-infizierten Müttern und ihren Kindern.
Wiener Med. Wschr. 147: 446 - 449; 1997.

Thiede C, Morgner A, Alpen B, Wündisch T, Herrmann J, Ritter M, Ehninger G, Stolte M, Bayerdörffer E, Neubauer A:
What role does Helicobacter pylori eradication play in gastric MALT and gastric MALT lymphoma?
Gastroenterology 113(6 Suppl):S61-S64, 1997

Schmidt M, Nagel S, Proba J, Thiede C, Ritter M, Waring JF, Rosenbauer F, Huhn D, Wittig B, Horak I, Neubauer A:
Lack of interferon consensus sequence binding protein (ICSBP) transcripts in human myeloid leukemias.
Blood, 91:22-29, 1998

Riewald M, Chuang T, Neubauer A, Riess H, Schleef RR:
Expression of bomapin, a novel human serpin, in normal / malignant hematopoiesis and the monocytic cell lines THP-1 and AML-193.
Blood 91: 1256-1262, 1998.

Bornhäuser M, Mohr B, Ehrenlechner U, Neubauer A, Ehninger G:
Fluorescence in situ hybridization for the BCR/ABL rearrangement is dependent on the percentage of non-lymphocytic cells in peripheral blood stem cell harvests.
J Hematotherapy, 7: 425-430, 1998.

Hiddemann W, Unterhalt M, Herrmann R, Wöltjen HH, Kreuser ED, Trümper L, Reuss-Borst M, Terhardt-Kasten E, Busch M, Neubauer A, Kaiser U, Hanrath RD, Middeke H, Helm G, Freund M, Stein H, Tiemann M, Parwaresch R:
Mantle-cell lymphomas have more widespread disease and a slower response to chemotherapy compared with follicle-center lymphomas: Results of a prospective comparative analysis of the German low-grade lymphoma study group.
J Clin Oncol 16: 1922-1930, 1998.

Fischer T, Neubauer A, Mohm J, Huhn D, Busemann C, Link H, Arseniev L, Büssing B, Novotny J, Ganser A, Duyster J, Bunkes D, Kreiter S, Aulitzky W, Hehlmann R, Huber C:
Chemotherapy induced mobilization of karyotypically normal PBSC for autografting in CML.
Bone Marrow Transplantion 21: 1029-1036, 1998.

Neubauer A, Thiede C, Neubauer B, Ehninger G, Bayerdörffer E, Stolte M:
Response to Dr. Seymour; Cure of Helicobacter pylori infection and duration of remission in low-grade gastric mucosa-associated lymphoid tissue lymphoma (Correspondence).
J Natl Cancer Inst 90: 164, 1998.

Thiede C, Alpen B, Morgner A, Schmidt M, Ritter M, Ehninger G, Stolte M, Bayerdörffer E, Neubauer A:
Ongoing somatic mutations and clonal expansions after cure of Helicobacter pylori infection in gastric mucosa associated lymphoid tissue (MALT) B-cell lymphoma.
J Clin Oncol 16: 3822-3831, 1998.

de Mas CR, Sefert E, Stolte M, Neubauer A, Thiede C:
An unusual course of a low-grade non-Hodgkin´s lymphoma of the stomach.
Z Gastroenterol 36: 567-569, 1998.

Baurmann H, Nagel S, Binder T, Neubauer A, Siegert W, Huhn D:
Kinetcs of the graft-versus leukemia response after donor leukocyte infusions for relapsed chronic myeloid leukemia after allogeneic bone marrow transplantation.
Blood 92: 3582-3590, 1998.

Müller M, Scheffold C, Lefterova P, Huhn D, Neubauer A, Schmidt-Wolf IGH:
Potential of autologous immunologic effector cells for prediction of progression of disease in patients with chronic myelogeneous leukemia.
Leuk Lymphoma 31: 335-341, 1998.

Heide I, Sokoll AC, Henz BM, Nagel S, Kreissig K, Grutzkau A, Grabbe J, Wittig B, Neubauer A.:
Regulation and possible function of axl expression in immature human mast cells.
Ann Hematol 77: 199-205, 1998.

Baurmann H, Thiede C, Nagel S, Neubauer A, Siegert W, Huhn D:
Chimerism following donor lymphocyte infusion for chronic myeloid leukemia (Correspondence).
Blood 93: 2748-49, 1999.

Thiede C, Florek M, Bornhäuser M, Ritter M, Mohr B, Brendel C, Ehninger G, Neubauer A:
Rapid quantification of mixed chimerism using multiplex amplification of short tandem repeat markers and fluorescence detection.
Bone Marrow Transplantation 23: 1055-60, 1999.

Rochlitz C, Lohri A, Bacchi M, Schmidt M, Nagel S, Fopp M, Fey MF, Herrmann R, Neubauer A:
Axl expression is associated with adverse prognosis and with expression of Bcl-2 and CD34 in de novo acute myeloid leukemia (AML): Results from a multicenter trial of the Swiss Group for Clinical Cancer Research (SAKK).
Leukemia, 13: 1352 - 1358, 1999.

Schmidt Wolf, IGH, Finke S, Trojanek B, Denkena A, Lefterova P, Schwella N, Heuft HG, Prange G, Korte M, Takeya M, Dorbic T, Neubauer A, Wittig B, Huhn D:
Phase I clinical study applying autologous immunologic effector cells transfected with the interleukin-2 gene in patients with metastatic renal cancer, colorectal cancer and lymphoma.
British Journal of Cancer 81: 1009-16, 1999.

Brendel C, Mohr B, Schimmelpfennig C, Müller J, Bornhäuser M, Schmidt M, Ritter M, Ehninger G, Neubauer A:
Detection of cytogenetic aberrations in CD90 (Thy-1) positive and negative stem cell (CD34) subfractions of patients with acute and chronic myeloid leukemias.
Leukemia, 13:1770-1775, 1999.

Illmer T, Schaich M, Oelschlägel U, Nowak R, Renner U, Ziegs B, Subat S, Neubauer A, Ehninger G:
A new PCR Mimic strategy to quantify low mdr1 mRNA levels in drug resistant cell lines and AML blast samples.
Leuk Res 23: 653-663, 1999.

Bornhäuser M, Thiede C, Brendel C, Geissler G, Oelschlägel U, Neubauer A, Ehninger G:
Stable engraftment after megadose blood stem cell transplantation across the HLA barrier.
Transplantation 63: 87-88, 1999.

Burchert A, Notter M, Menssen HD, Schwartz S, Knauf W, Neubauer A, Thiel E:
CD82 (Kai 1) , a member of the tetraspanin family, is expressed on early hematopoietic progenitor cells and up-regulated in distinct human leukemias.
Br J Haematol 107: 494-504, 1999.

Ruhnke M, Grosch-Wörner, I, Lischewski A, Neubauer A, Steinmüller A, Trautmann M, Morschhäuser J:
Genotypic relatedness of yeast isolates from women infected with human immunodeficiency virus and their children.
Mycoses 42: 385-394, 1999.

Lindauer M, Domkin D, Döhner H, Kolb H, Neubauer A, Huhn D, Kreiter H, Koch B, Huber C, Aulitzky W, Fischer T:
Efficacy and toxicity of IFN-alpha2b combined with cytarabine in chronic myelogeneous leukemia.
Br J Haematol 106: 1013-19, 1999.

Ochsenkühn T, Bayerdörffer E, Meining A, Schinkel M, Thiede C, Nussler V, Sackmann M, Hatz R, Neubauer A, Paumgartner G:
Colonic mucosal proliferation is related to serum deoxycholic acid levels.
Cancer 85: 1664-69, 1999

Behn M, Thiede C, Neubauer A, Pankow W, Schuermann M:
Facilitated detection of oncogene mutations from exfoliated tissue material by a PNA mediated enriched PCR protocol.
J Pathol 190, 190: 69-75, 2000.

Alpen B, Dierlamm J, Marynen P, Thiede C, Bayerdörffer E, Stolte M, Neubauer A:
The translocation t (11; 18) is absent in early gastric marginal zone B-cell lymphoma of MALT type responding to cure of Helicobactter pylori infection (letter).
Blood 2000, 95: 4014-4015, 2000.

Morgner A, Lehn N, Andersen LP, Thiede C, Bennedsen M, Trebesius K, Neubauer B, Neubauer A, Stolte M, Bayerdörffer E:
Helicobacter Heilmannii associated primary gastric low grade MALT lymphoma: Complete remission after curing the infection.
Gastroenterology 118: 821-828, 2000.

Schmidt M, Hochhaus A, König-Merediz SA, Brendel C, Proba J, Hoppe G, Wittig B, Ehninger G, Hehlmann R, Neubauer A:
Expression of interferon regulatory factor 4 in chronic myeloid leukemia: Correlation with response to interferon-alpha therapy.
J Clin Oncol. 18: 3331-3338, 2000.

Bornhäuser M, Thiede C, Schuler U, Platzbecker U, Freiberg-Richter J, Helwig A, Plettig R, Röllig C, Naumann R, Kroschinsky F, Neubauer A, Ehninger G:
Dose reduced conditioning for allogeneic blood stem cell transplantation: durable engraftment without antithymocyte globulin.
Bone Marrow Transplantation 26: 119-125, 2000.

Schmidt M, Müller J, Proba J, Ehninger G, Neubauer A:
Transfection of receptor tyrosine kinase axl into human haematopoietic cells does not cause spontaneous cellular aggregation (Correspondence).
Br J Haematol 110: 1004 – 1005, 2000.

König Merediz SA, Schmidt M, Hoppe GJ, Alfken J, Meraro D, Levi BZ, Neubauer A, Wittig B:
Cloning of the interferon regulatory factor 2 isoform with different regulatory activity.
Nucl Acids Res 28: 4219-4224, 2000.

Hildebrandt B, Heide I, Thiede C, Nagel S, Dieing A, Jonas S, Neuhaus P, Rochlitz C, Riess H, Neubauer A:
Lack of point mutations in exons 11-23 of the retinoblastoma susceptibility gene RB-1 in liver metastases of colorectal carcinoma.
Oncology 59: 344-346, 2000.

Scheffold C, Schöttker B, Lefterova P, Csipai M, Glasmacher A, Huhn D, Neubauer A, Schmidt Wolf IGH:
Increased sensitivity of myeloid leukemia cell lines: Potential of lovastatin as bone marrow purging agent.
Acta Haematologica 104: 72-79, 2000.

Dennhardt N, Gorg C, Neubauer A.:
Frequency, pattern and differential diagnosis of echogenic splenic changes: sonographic follow-up study.
Ultraschall Med :151-159, 2000.

Thiede C, Wündisch T, Alpen B, Neubauer B, Morgner A, Schmitz M, Ehninger G, Stolte M, Bayerdörffer E, Neubauer A:
Long term persistence of monoclonal B-cells after cure of Helicobacter pylori infection and obtaining complete histological remission in gastric mucosa associated lymphoid tissue (MALT) B cell lymphoma.
J. Clin. Oncol., 19: 1600-1609, 2001.

Wieser R, Schreiner U, Wollenberg B, Neubauer A, Fonatsch C, Rieder H:
Masked inv (3) (q21Q26) in a patient with minimally differentiated acute myeloid leukemia (Correspondence).
Haematologica 86: 214-215, 2001.

Morgner A, Miehlke S, Fischbach W, Schmitt W, Müller-Hermelink HK, Geiner A, Thiede C, Schetelig J, Neubauer A, Stolte M, Ehninger G, Bayerdörffer E:
Complete remission of primary high grade B-cell gastric lymphoma after cure of Helicobacter pylori infection.
J Clin Oncol, 19: 2041-2048, 2001.

Wittig B, Märten A, Dorbic T, Weineck S, Min H, Nemitz S, Trojaneck B, Flieger D, Kruopis S, Albers A, Löffel J, Neubauer A, Albers P, Müller S, Sauerbruch T, Bieber T, Huhn D, Schmidt-Wolf IGH:
Therapeutic vaccination against metastatic carcinoma by expression-modulated and immunomodified autologous tumor cells: A first clinical phase I/II trial.
Human Gene Therapy, 12: 267-278, 2001.

Thiede C, Bornhäuser M, Oelschlägel U, Brendel C, Daxberger H, Mohr B, Florek M, Kroschinsky F, Geissler G, Naumann R, Ritter M, Prange Krex G, Lion T, Neubauer A, Ehninger G:
Sequential monitoring of chimerism and detection of minimal residual disease after allogeneic blood stem cell transplantation using multiplex PCR amplification of short tandem repeat markers.
Leukemia 15: 293-302, 2001.

Schaich M, Ritter M, Illmer T, Lisske P, Thiede C, Schäkel U, Mohr B, Ehninger G, Neubauer A:
Mutations in the ras proto-oncogenes are associated with lower mdr-1 gene expression in adult acute myeloid leukemia.
Br J Haematol 112: 300-307, 2001.

Schmidt M, Hochhaus A, Nitsche A, Hehlmann R, Neubauer A:
Expression of nuclear transcription factor interferon consensus sequence binding protein in chronic myeloid leukemia correlates with pretreatment risk features and cytogenetic response to interferon-alpha.
Blood 97: 3648-3650, 2001.

Reckzeh B, Grebe SO, Rhiele I, Neubauer A, Müller TF:
Monitoring of ATG therapy by flow cytometry: comparison of one single platform and two different dual platform methods.
Transplantation Proceedings 33: 2234-2236, 2001.

Alpen B, Röbbecke J, Wündisch T, Stolte M, Neubauer A:
Helicobacter pylori eradication therapy in gastric high grade non Hodgkin´s lymphoma.
Ann Hematology, 80: B106-107, 2001.

Thiede C, Steudel C, Mohr B, Schaich M, Schäkel U, Platzbecker U, Wermke M, Bornhäuser M, Ritter M, Neubauer A, Ehninger G, Illmer T:
Quantitative determination FLT3 internal repeat mutations defines a subgroup of poor prognosis in intermediate risk AML.
Blood 99: 4326-4335, 2002.

Liu, H., Ye, H., Ruskone-Fourmestraux, A., De Jong, D., Pileri, S., Thiede, C., Lavergne, A., Boot, H., Caletti, G., Wündisch, T., Molina, T., Taal, B. G., Elena, S., Thomas, T., Zinzani, P. L., Neubauer, A., Stolte, M., Hamoudi, R. A., Dogan, A., Isaacson, P. G., Du, M. Q. Liu, H.:
t(11;18) is a marker for all stage gastric MALT lymphomas that will not respond to H. pylori eradication.
Gastroenterology 122: 1286-1294, 2002.

Jäger, R., List, B., Knabbe, C., Souttou, B., Raulais, D., Zeiler, T.,Wellstein, A., Aigner, A., Neubauer, A., Zugmaier, G:
Serum levels of the angiogenic factor pleiotrophin in relation to disease stage in lung cancer patients.
Br J Cancer 86: 858-863, 2002.

Schaich M, Illmer T, Aulitzky W, Bodenstein H, Clemens M, Neubauer A, Repp R, Schäkel U, Soucek S, Wandt H, Ehninger G:
Intensified double induction therapy with high dose mitoxantrone, etoposide, m-amsacrine, and high dose ara-C for patients aged 61-65 years with acute myeloid leukemia.
Haematologica 87: 808-817, 2002.

Ritter M, Mutters R, Schwella N, Beyer J, Wündisch Th, Rüdiger H, von Jan K, Neubauer A:
Herstellung von Blutstammzellprodukten unter Reinraumbedingungen der Klasse A mit Hintergrundbedingungen der Klasse B (Teil 1).
Pharm Ind 64: 601-606, 2002

Ritter M, Mutters R, Schwella N, Beyer J, Wündisch Th, Rüdiger H, von Jan K, Neubauer A:
Herstellung von Blutstammzellprodukten unter Reinraumbedingungen der Klasse A mit Hintergrundbedingungen der Klasse B (Teil 2).
Pharm Ind 64: 701-707, 2002

Johan Vansteenkiste, Robert Pirker, Bartomeu Massuti, Fernando Barata,Albert Font, Michael Fiegl, Salvatore Siena, Jenni Gateley, Dianne Tomita,Alan B. Colowick, Jaromir Musil, and the Aranesp ™ 980297 Study Group (darunter auch A.Neubauer):
Double blind, placebo controled, randomized phase III trial of darbepoetin alpha in lung cancer patients receiving chemotherapy.
J Natl Cancer Inst 94: 1211-1220, 2002.

Schetelig, J., Thiede, C., Bornhauser, M., Schwerdtfeger, R., Kiehl, M., Beyer, J., Kroger, N., Hensel, M., Scheffold, C., Ho, A. D., Kienast, J., Neubauer, A., Zander, A. R., Fauser, A. A., Ehninger, G., Siegert, W.:
Reduced non-relapse mortality after reduced intensity conditioning in advanced chronic lymphocytic leukemia.
Ann Hematol 81 Suppl 2: S47-8, 2002.

Thiede, C, Lutterbeck, K., Oelschlagel, U., Kiehl, M., Steudel, Ch, Platzbecker, U., Brendel, C., Fauser, A. A., Neubauer, A., Ehninger, G., Bornhauser, M.:
Detection of relapse by sequential monitoring of chimerism in circulating CD34+ cells.
Ann Hematol 81 Suppl 2: S 27-28, 2002.

Burchert A., Wölfl S, Schmidt M, Brendel C, Denecke B, Cai D, Odyvanova L, Lahaye T, Müller MC, Berg T, Gschaidmeier H, Wittig B, Hehlmann R, Hochhaus A, Neubauer A:
Interferon - alpha, but not the ABL kinase inhibitor imatinib induces expression of myeloblastin and a sepcific T-cell response in chronic myeloid leukemia.
Blood 101: 259 – 64, 2003.

Kaiser, U., Zugmaier, G., Frank, M., Riedel, I., Neubauer, A., Moll, R.:
AFP-producing adenocarcinoma of the stomach. A rare tumor with poor prognosis (Case report).
Pathologe 24, 141-145, 2003.

Wündisch T, Neubauer A, Stolte M, Ritter M, Thiede C:
B-cell Monoclonality Is Associated With Lymphoid Follicles in Gastritis.
Am J Surg Pathol 27: 882-887, 2003.

Schetelig J, Thiede C, Bornhäuser M, Schwerdtfeger R, Kiehl M, Beyer J, Sayer HG, Kröger N, Hensel M, Scheffold C, Held TK, Höffken K, Ho AD, Kienast J, Neubauer A, Zander AR, Fauser AA, Ehninger G, Siegert W:
Evidence of a graft versus leukemia effect in chronic lymphocytic leukemia after reduced intensity conditioning and allogeneic stem cell transplantation: The cooperative German transplant study group.
J Clin Oncol 21: 2747-53, 2003.

Alpen B, Wündisch T, Dierlamm J, Börsch G, Stolte M, Neubauer A:
Clonal relationship in multifocal non-Hodgkin ’s lymphoma of mucosa-associated lymphoid tissue(MALT).
Ann Hematol 83: 124-126, 2004.

Aigner A, Brachmann P, Beyer J, Jäger R, Raulais D, Vigny M, Neubauer A, Heidenreich A, Weinknecht S, F. Czubayko F, Zugmaier G:
Marked increase of the growth factors pleiotrophin and fibroblast growth factor-2 in serum of testicular cancer patients.
Ann Oncol 14: 1525-1529, 2003.

Müller MC, Gattermann N, Lahaye T, Deininger MWN, Berndt A, Fruehauf S, Neubauer A, Fischer T, Hossfeld DK, Schneller F, Krause SW, Nerl C, Sayer HG, Ottmann OG, Waller C, Aulitzky W. le Coutre P, Freund M, Merx K, Paschka P, König H, Kreil S, Berger U, Gschaidmeier H, Hehlmann R and Hochhaus A:
Dynamics of BCR-ABL mRNA expression in first-line therapy of chronic myelogenous leukemia patients with imatinib or interferon a/ara-C.
Leukemia, 1-9, 2003.

Ritter M, Schwedler J, Beyer J, Movassaghi K, Mutters R, Neubauer A, and Schwella N:
Bacterial contamination of ex vivo processed PBPC products under clean room conditions.
Transfusion 43: 1587-1595, 2003.

Burchert A, Cai D, Hofbauer L, Samuelsson M, Slater EP, Duyster J, Ritter M, Hochhaus A, Müller R, Eilers M, Schmidt M, and Neubauer A:
Interferon Consensus Sequence Binding Protein (ICSBP, IRF-8) antagonizes BCR/ABL and down-regulates bcl-2.
Blood 103: 3480-89, 2004.

Hofbauer LC, Neubauer A, Schoppet M:
DKK1 in multiple myeloma (letter).
New Engl J Med 350: 1464-65, 2004.

Hehlmann, R., Berger, U., Aul, C., Buchner, T., Dohner, H., Ehninger, G., Ganser, A., Gokbuget, N., Hoelzer, D., Uberla, K., Gassmann, W., Ludwig, W. D., Rieder, H., Kneba, M., Hochhaus, A., Reiter, A., Hiddemann, W., Ottmann, O. G., Germing, U., Adelhard, K., Dugas, M., Dirschedl, P., Messerer, D., Bohme, A., Harrison-Neu, E., Griesshammer, M., Kienast, J., Kolb, H. J., Ho, A. D., Hallek, M., Neubauer, A., Schlegelberger, B., Niederwieser, D., Heil, G., Muller, T., Hasford, J.:
The German competence network 'Acute and chronic leukemias'.
Leukemia 18: 665-669, 2004.

Alpen B, Kuse R, Parwaresch R, Müller-Hermelink HK, Stolte M, Neubauer A:
Ongoing Monoclonal B-Cell Proliferation Is Not Common in Gastric B-cell Lymphoma After Combined Radiochemotherapy.
J Clin Oncol 2004; 22:3039-3045. 

Ritter M, Kim T, Lisske P, Thiede C, Schaich M, Neubauer A:
Prognostic significance of N-ras and K-ras mutations in 232 patients with acute myeloid leukemia (letter).
Haematologica 89: 1397-99, 2004.

Görg C, Wollenberg B, Beyer J, Stolte MS, Neubauer A:
High-resolution ultrasonography in gastrointestinal graft-versus-host disease.
Ann Hematol 84: 33-39, 2005.

Illmer T, Thiede, C., Fredersdorf, A., Stadler, S., Neubauer, A., Ehninger, G., Schaich, M.:
Activation of the RAS pathway is predictive for a chemosensitive phenotype of acute myelogenous leukemia blasts.
Clin Cancer Res, 11: 3217-24, 2005

Seifart U, Jensen K, Ukena J, Mueller C, Schröder M, Fuhr HG, Keppler U, Neubauer A, Staab HJ, Wolf M:
Randomized phase II study comparing topotecan cisplatinum administration for 5 days versus 3 days in the treatment of extensive stage small cell lung cancer (SCLC).
Lung cancer 2005; 48: 415-422.

Stelljes M, Bornhäuser M, Kröger M, Beyer J, Sauerland MC, Heinecke A, Berning B, Scheffold C, Silling G, Büchner T, Neubauer A, Fauser AA, Ehninger G, Berdel W, Kienast J:
Conditioning with 8 Gy total body irradiation and fludarabine for allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia.
Blood, in press

Burchert A., Wang Y, Cai D, Bubnoff Nv, Paschka P, Müller-Brüsselbach S, Ottmann OG, Duyster J, Hochhaus A, Neubauer A:
Compensatory PI3-Kinase/Akt/mTor activation regulates Imatinib resistance development.
Leukemia, 19: 1774-82, 2005.

Rinn J, Schwella N, Wollmer E, Jaques G, Heinzel-Gutenbrunner M, Strassmann G, Gross MW, Movassaghi K, Neubauer A, Ritter M:
Local irradiation prior to stem cell harvest has no influence on CD34+ yield: a quantitative analysis.
Ann Hematol, in press.

Lenz, G.,Dreyling, M., Hoster, E., Wormann, B., Duhrsen, U., Metzner, B., Eimermacher, H., Neubauer, A., Wandt, H., Steinhauer, H., Martin, S., Heidemann, E., Aldaoud, A., Parwaresch, R., Hasford, J., Unterhalt, M., Hiddemann, W.:
Immunochemotherapy With Rituximab and Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone Significantly Improves Response and Time to Treatment Failure, But Not Long-Term Outcome in Patients With Previously Untreated Mantle Cell Lymphoma: Results of a Prospective Randomized Trial of the German Low Grade Lymphoma Study Group (GLSG).
J. Clin. Oncol. 23 (9): 1984-1992, 2005.

Wündisch T, Thiede C, Morgner A, Dempfle A, Günther A, Liu H, Ye H, Du M, Kim TD, Bayerdörffer E, Stolte M, Neubauer A:
Long-term follow-up of 120 patients with gastric MALT lymphoma after Helicobacter pylori eradication.
J Clin Oncol, 2005 in press

Dickhut A, Schwerdtfeger R, Kuklick L, Ritter M, Thiede C, Neubauer A, Brendel C:
Mesenchymal stem cells obtained after bone marrow transplantation or peripheral blood stem cell transplantation originate from host tissue.
Ann Hematol 84: 722-727, 2005.

Cai D, Wang Y, Ottmann OG, Barth PJ, Neubauer A, Burchert A:
FLT3-ITD-, but not BCR/ABL-transformed cells require concurrent Akt/mTor blockage to undergo apoptosis after histone deacetylase inhibitor treatment.
Blood, 2005, in press.

Mitgliedschaften

Mitglied der Nationalen Akademie der Wissenschaften Leopoldina
(2014)

Wissenschaftlicher Beirat der Deutschen José Carreras Leukämiestiftung

Wissenschaftlicher Beirat der Deutschen Gesellschaft für Hämatologie und internistische Onkologie
(Oktober 1997)

American Society of Clinical Oncology
(01/99)

American Society of Clinical Oncology
(01/99)

Deutsche Gesellschaft für Innere Medizin
(04/98)

Deutsche Arbeitsgemeinschaft für Gentherapie
(10/94)

Berliner Krebsgesellschaft
(10/1994)

European Hematology Association
(05/1994)

Deutsche Krebsgesellschaft
(05/1994)

American Society of Hematology
(01/1994)

Cancer and Leukemia Group B
(01/1991)

American Association for the Advancement of Science
(05/1989)

Deutsche Gesellschaft für Hämatologie und Onkologie
(01/1988)